| Last updated: Sun, November 30, 2008, 16:47 EST |
| Date | Player | Pos. | Transaction |
| 11/28 | Wes Littleton | P | Traded From, Texas (for future considerations) |
| 11/19 | Ramon Ramirez | P | Traded From, Kansas City (for CF Coco Crisp) |
| 11/4 | Mike Timlin | P | Declared Free Agency |
| 11/3 | Paul Byrd | P | Declared Free Agency |
| 11/3 | Paul Byrd | P | Declared Free Agency |
| 11/1 | Mark Kotsay | CF | Declared Free Agency |
| 10/31 | Sean Casey | 1B | Declared Free Agency |
| 10/31 | Bartolo Colon | P | Reinstated From Restricted List |
| 10/31 | Bartolo Colon | P | Declared Free Agency |
| 10/31 | Tim Wakefield | P | Signed, ( 2009)(team option exercised) |
| 10/31 | Curt Schilling | P | Declared Free Agency |
| 10/31 | Curt Schilling | P | Removed From 60-Day DL, (Right shoulder surgery - out for season) |
| 10/30 | Jason Varitek | C | Declared Free Agency |
| 10/30 | David Ross | C | Declared Free Agency |
| 10/30 | Alex Cora | SS | Declared Free Agency |
| 10/28 | Virgil Vasquez | P | Acquired Off Waivers From, Detroit |
| 10/23 | Gil Velazquez | SS | Outrighted to Minors |
| 10/22 | Chris Smith | P | Refused Minor League Assignment - Free Agent |
| 10/17 | Dewon Day | P | Acquired Off Waivers From, Chi. White Sox |
| 10/17 | Chris Smith | P | Designated for Assignment |
| 9/25 | Gil Velazquez | SS | Purchased From Minors |
| 9/19 | Bartolo Colon | P | Placed on Restricted List |
| 9/13 | Hideki Okajima | P | Signed, ( 2009)(team option exercised) |
| 9/12 | Jonathan Van Every | CF | Called Up from Minors |
| 9/10 | David Aardsma | P | Removed From 15-Day DL, (Strained right groin) |
| 9/9 | Bartolo Colon | P | Called Up from Minors |
| 9/8 | Chris Carter | LF | Called Up from Minors |
| 9/8 | J.D. Drew | RF | Removed From 15-Day DL, (Herniated disc) |
| 9/7 | Bartolo Colon | P | Removed From 60-Day DL, (Back stiffness) |
| 9/7 | Marcus McBeth | P | Designated for Assignment |
| 9/7 | Devern Hansack | P | Called Up from Minors |
| 9/7 | Bartolo Colon | P | Sent to Minors |
| 9/7 | Bartolo Colon | P | Recalled From Minors, Rehab Assignment |
| 9/5 | Mike Lowell | 3B | Removed From 15-Day DL, (Right oblique strain) |
| 9/5 | Josh Beckett | P | Removed From 15-Day DL, (Right elbow inflammation) |
| 9/5 | Sean Casey | 1B | Removed From 15-Day DL, (Strained neck) |
| 9/5 | Eric Hull | P | Outrighted to Minors |
| 9/3 | Jonathan Van Every | CF | Sent to Minors |
| 9/2 | Chris Smith | P | Called Up from Minors |
| 8/31 | Michael Bowden | P | Sent to Minors |
| 8/30 | Michael Bowden | P | Purchased From Minors |
| 8/29 | Sean Casey | 1B | Placed on 15-Day DL, (Strained neck) |
| 8/29 | Josh Beckett | P | Placed on 15-Day DL, (Right elbow inflammation) |
| 8/29 | David Ross | C | Purchased From Minors |
| 8/27 | Mark Kotsay | CF | Cleared Waivers/Traded, Atlanta (for OF Luis Sumoza) |
| 8/27 | Joe Thurston | LF | Designated for Assignment |
| 8/26 | Tim Wakefield | P | Removed From 15-Day DL, (Right shoulder tightness) |
| 8/26 | Joe Thurston | LF | Purchased From Minors |
| 8/26 | Bartolo Colon | P | Transferred to 60-Day DL, (Back stiffness) |
| 8/26 | J.D. Drew | RF | Placed on 15-Day DL, (Herniated disc) |
| 8/26 | Chris Smith | P | Sent to Minors |
| 8/23 | David Aardsma | P | Placed on 15-Day DL, (Strained right groin) |
| 8/23 | David Pauley | P | Called Up from Minors |
| 8/22 | David Ross | C | Signed to a Minor League Contract |
| 8/22 | Chris Smith | P | Called Up from Minors |
| 8/21 | Clay Buchholz | P | Sent to Minors |
| 8/19 | Jason Lane | CF | Signed to a Minor League Contract |
| 8/14 | Jeff Bailey | LF | Called Up from Minors |
| 8/14 | David Pauley | P | Sent to Minors |
| 8/13 | Marcus McBeth | P | Acquired Off Waivers From, Cincinnati |
| 8/13 | Marcus McBeth | P | Sent to Minors |
| 8/13 | Mike Lowell | 3B | Placed on 15-Day DL, (Right oblique strain) |
| 8/13 | David Pauley | P | Called Up from Minors |
| 8/13 | Charlie Zink | P | Sent to Minors |
| 8/12 | Tim Wakefield | P | Placed on 15-Day DL, (Right shoulder tightness) |
| 8/12 | Paul Byrd | P | Traded From, Cleveland (for player to be named) |
| 8/12 | Charlie Zink | P | Purchased From Minors |
| 8/8 | David Aardsma | P | Recalled From Minors, Rehab Assignment |
| 8/8 | David Aardsma | P | Removed From 15-Day DL, (Strained right groin) |
| 8/7 | Chris Smith | P | Sent to Minors |
| 8/5 | Bartolo Colon | P | Sent to Minors, For Rehabilitation |
| 8/3 | David Aardsma | P | Sent to Minors, For Rehabilitation |
| 8/2 | Josh Wilson | SS | Traded From, Pittsburgh (for player to be named) |
| 8/1 | Chris Smith | P | Called Up from Minors |
| 7/31 | Brandon Moss | RF | Called Up from Minors, - Not to Report |
| 7/31 | Andy LaRoche | 3B | Traded From, Los Angeles |
| 7/31 | Jason Bay | LF | Traded From, Pittsburgh (for OF Manny Ramirez in six-player deal) |
| 7/25 | David Ortiz | DH | Removed From 15-Day DL, (Torn tendon sheath in left wrist) |
| 7/25 | David Ortiz | DH | Recalled From Minors, Rehab Assignment |
| 7/24 | Brandon Moss | RF | Sent to Minors |
| 7/20 | Justin Masterson | P | Called Up from Minors |
| 7/20 | David Aardsma | P | Placed on 15-Day DL, (Strained right groin) |
| 7/17 | David Ortiz | DH | Sent to Minors, For Rehabilitation |
| 7/12 | Julio Lugo | SS | Placed on 15-Day DL, (Strained left quad) |
| 7/12 | Jed Lowrie | 3B | Called Up from Minors |
| 7/11 | Clay Buchholz | P | Called Up from Minors |
| 7/9 | Jeff Bailey | LF | Sent to Minors |
| 7/7 | Jeff Bailey | LF | Called Up from Minors |
| 7/7 | Justin Masterson | P | Sent to Minors |
| 7/3 | Coco Crisp | CF | Reinstated From League Suspension |
| 7/3 | Mike Timlin | P | Removed From 15-Day DL, (Left knee tendinitis) |
| 7/3 | Mike Timlin | P | Recalled From Minors, Rehab Assignment |
| 7/2 | Chris Smith | P | Sent to Minors |
| 6/28 | Coco Crisp | CF | Starting to Serve Suspension |
| 6/27 | Sean Casey | 1B | Reinstated From League Suspension |
| 6/26 | Mike Timlin | P | Sent to Minors, For Rehabilitation |
| 6/23 | Sean Casey | 1B | Starting to Serve Suspension |
| 6/21 | Daisuke Matsuzaka | P | Recalled From Minors, Rehab Assignment |
| 6/21 | Daisuke Matsuzaka | P | Removed From 15-Day DL, (Mild right rotator cuff strain) |
| 6/21 | Mike Timlin | P | Placed on 15-Day DL, (Left knee tendinitis) |
| 6/17 | Bartolo Colon | P | Placed on 15-Day DL, (Back stiffness) |
| 6/16 | Daisuke Matsuzaka | P | Sent to Minors, For Rehabilitation |
| 6/8 | Dave Gassner | P | Signed to a Minor League Contract |
| 6/6 | Brandon Moss | RF | Called Up from Minors |
| 6/6 | Sean Casey | 1B | Suspension Announced By League, (three games) |
| 6/6 | Coco Crisp | CF | Suspension Announced By League, (seven games) |
| 6/6 | Jon Lester | P | Suspension Announced By League, (five games) |
| 6/6 | Chris Carter | 1B | Sent to Minors |
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