| Last updated: Wed, November 26, 2008, 08:12 EST |
| Date | Player | Pos. | Transaction |
| 11/24 | Jamie D'Antona | 1B | Signed to Play in Japan, (Tokyo Yakult Swallows) |
| 11/24 | Jamie D'Antona | 1B | Released |
| 11/16 | Eric Byrnes | LF | Removed From 60-Day DL, (Strained left hamstring) |
| 11/13 | Randy Johnson | P | Declared Free Agency |
| 11/3 | Edgar Gonzalez | P | Outrighted to Minors |
| 11/3 | Brandon Lyon | P | Declared Free Agency |
| 11/3 | Edgar Gonzalez | P | Outrighted to Minors |
| 11/3 | Brandon Lyon | P | Declared Free Agency |
| 11/1 | Orlando Hudson | 2B | Removed From 60-Day DL, (Dislocated left wrist - out for season) |
| 11/1 | Adam Dunn | LF | Declared Free Agency |
| 11/1 | Orlando Hudson | 2B | Declared Free Agency |
| 10/31 | Tony Clark | 1B | Declared Free Agency |
| 10/31 | Jon Rauch | P | Signed, ( 2010)(team option exercised) |
| 10/30 | Juan Cruz | P | Declared Free Agency |
| 10/30 | David Eckstein | SS | Declared Free Agency |
| 9/12 | Micah Owings | P | Called Up from Minors, - Not to Report |
| 9/2 | Josh Whitesell | 1B | Called Up from Minors |
| 9/2 | Alex Romero | RF | Called Up from Minors |
| 9/2 | Doug Slaten | P | Called Up from Minors |
| 9/2 | Leo Rosales | P | Called Up from Minors |
| 9/2 | Jamie D'Antona | 1B | Called Up from Minors |
| 9/2 | Billy Buckner | P | Called Up from Minors |
| 9/1 | Robby Hammock | C | Called Up from Minors |
| 9/1 | Jailen Peguero | P | Called Up from Minors |
| 8/31 | David Eckstein | SS | Traded From, Toronto (for RHP Chad Beck) |
| 8/31 | Emiliano Fruto | P | Designated for Assignment |
| 8/30 | Billy Buckner | P | Sent to Minors |
| 8/29 | Wil Ledezma | P | Acquired Off Waivers From, San Diego |
| 8/29 | Alex Romero | RF | Sent to Minors |
| 8/29 | Leo Rosales | P | Sent to Minors |
| 8/29 | Max Scherzer | P | Called Up from Minors |
| 8/29 | Justin Upton | RF | Recalled From Minors, Rehab Assignment |
| 8/29 | Justin Upton | RF | Removed From 15-Day DL, (Left oblique strain) |
| 8/24 | Billy Buckner | P | Called Up from Minors |
| 8/24 | Doug Slaten | P | Sent to Minors |
| 8/13 | Doug Slaten | P | Removed From 15-Day DL, (Strained right knee) |
| 8/13 | Doug Slaten | P | Recalled From Minors, Rehab Assignment |
| 8/13 | Billy Buckner | P | Sent to Minors |
| 8/13 | Jamie D'Antona | 3B | Sent to Minors |
| 8/11 | Justin Upton | RF | Sent to Minors, For Rehabilitation |
| 8/11 | Orlando Hudson | 2B | Transferred to 60-Day DL, (Dislocated left wrist - out for season) |
| 8/11 | Adam Dunn | LF | Traded From, Cincinnati (for RHP Dallas Buck in four-player deal) |
| 8/10 | Orlando Hudson | 2B | Placed on 15-Day DL, (Dislocated left wrist - out for season) |
| 8/10 | Jeff Salazar | LF | Purchased From Minors |
| 8/10 | Edgar Gonzalez | P | Transferred to 60-Day DL, (Strained right elbow) |
| 8/5 | Dan Haren | P | Signed, ( 2009-2012; Opt 2013)(four-year extension) |
| 8/3 | Doug Slaten | P | Sent to Minors, For Rehabilitation |
| 8/2 | Juan Cruz | P | Recalled From Minors, Rehab Assignment |
| 8/2 | Jailen Peguero | P | Sent to Minors |
| 8/2 | Juan Cruz | P | Removed From 15-Day DL, (Left oblique strain) |
| 7/29 | Micah Owings | P | Sent to Minors |
| 7/29 | Jailen Peguero | P | Called Up from Minors |
| 7/22 | Eric Byrnes | LF | Transferred to 60-Day DL, (Strained left hamstring) |
| 7/22 | Jamie D'Antona | 3B | Purchased From Minors |
| 7/22 | Jon Rauch | P | Traded From, Washington (for 2B Emilio Bonifacio) |
| 7/22 | Connor Robertson | P | Sent to Minors |
| 7/20 | Robby Hammock | C | Sent to Minors |
| 7/20 | Chris Snyder | C | Recalled From Minors, Rehab Assignment |
| 7/20 | Chris Snyder | C | Removed From 15-Day DL, (Left testicular fracture) |
| 7/19 | Billy Buckner | P | Called Up from Minors |
| 7/19 | Doug Slaten | P | Placed on 15-Day DL, (Strained right knee) |
| 7/18 | Justin Upton | RF | Placed on 15-Day DL, (Left oblique strain) |
| 7/18 | Chris Snyder | C | Sent to Minors, For Rehabilitation |
| 7/17 | Tony Clark | 1B | Traded From, San Diego (for RHP Evan Scribner) |
| 7/9 | Jeff Salazar | LF | Outrighted to Minors |
| 7/7 | Connor Robertson | P | Called Up from Minors |
| 7/7 | Juan Cruz | P | Placed on 15-Day DL, (Left oblique strain) |
| 7/4 | Connor Robertson | P | Sent to Minors |
| 7/4 | Alex Romero | CF | Called Up from Minors |
| 7/4 | Jeff Salazar | LF | Designated for Assignment |
| 7/4 | Emilio Bonifacio | 2B | Called Up from Minors |
| 7/1 | Connor Robertson | P | Purchased From Minors |
| 7/1 | Robby Hammock | C | Called Up from Minors |
| 7/1 | Eric Byrnes | LF | Placed on 15-Day DL, (Strained left hamstring) |
| 7/1 | Chris Snyder | C | Placed on 15-Day DL, (Left testicular fracture) |
| 6/28 | Edgar Gonzalez | P | Placed on 15-Day DL, (Strained right elbow) |
| 6/28 | Yusmeiro Petit | P | Called Up from Minors |
| 6/23 | Eric Byrnes | LF | Recalled From Minors, Rehab Assignment |
| 6/23 | Eric Byrnes | LF | Removed From 15-Day DL, (Strained right hamstring) |
| 6/23 | Alex Romero | CF | Sent to Minors |
| 6/19 | Eric Byrnes | LF | Sent to Minors, For Rehabilitation |
| 6/15 | Leo Rosales | P | Called Up from Minors |
| 6/15 | Billy Buckner | P | Sent to Minors |
| 6/13 | Billy Buckner | P | Called Up from Minors |
| 6/13 | Max Scherzer | P | Sent to Minors |
| 5/31 | Brandon Medders | P | Outrighted to Minors |
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